Российский кардиологический журнал (Dec 2017)

QUALITATIVE TEST FOR THE FATTY ACID BINDING CARDIAC PROTEIN IN EARLY DIAGNOSTICS OF MYOCARDIAL INFARCTION: SUBANALYSIS OF RUSSIAN MULTI-CENTER STUDY ISPOLIN

  • V. A. Kokorin,
  • М. Z. Gasanov,
  • I.  G. Gordeev,
  • А. М. Gritsanchuk,
  • N. А. Dzhaiani,
  • R. М. Kalinichenko,
  • V. V. Kashtalap,
  • F. Yu. Kopylov,
  • I. V. Kositsyna,
  • Е. S. Kylbanova,
  • Е. S. Lapina,
  • Е. D. Laryushkina,
  • V. N. Nikanorov,
  • А. V. Khripun,
  • S. S. Yakushin

DOI
https://doi.org/10.15829/1560-4071-2017-11-62-67
Journal volume & issue
Vol. 0, no. 11
pp. 62 – 67

Abstract

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Aim. To specify diagnostic characteristics of the test for qualitative measurement of the fatty acid binding protein, cardiac fraction (cFABP), in patients with suspected acute coronary syndrome (ACS) based on the subanalysis of ISPOLIN study.Material and methods. To the subanalysis, 592 patients included, admitted to inpatient institutions of 8 centers in 5 cities, with suspected ACS during 24 hours from the onset of clinical signs. At admittance, all patients underwent cFABP test in whole venous blood with immune chromatography express test “CardioFABP” (SPI “Biotest”, Novosibirsk, Russia) and level of cardiac troponin I by qualitative and quantitative methods. For both markers, the values were assessed of sensitivity, specificity, diagnostic accuracy, positive and negative predictive value in general, and various timing intervals from the moment of clinical ACS signs presentation and ECG changes.Results. During first 6 hours from the pain onset, cFABP test performed better than cTnI by sensitivity, diagnostic accuracy and negative predictive significane (p<0,01), and no worse than specificity and positive predictive value (p>0,05). With the pain less than 3 hours and 3-6 hours, ROC areas for cFABP are better than those for cTnI. With the duration of clinical signs more than 6 hours, sensitivity and diagnostic accuracy were better than of cTnI. In anamnesis of the patients with false positive results of cFABP test there were kidney diseases and anemia. They also had GFR <30 mL/min/1,73 m2 at admission and higher in-hospital mortality (p<0,01).Conclusion. Qualitative express-test “CardioFABP” makes it to more accurately diagnose MI at early stages of the disease comparing to cTnI. The test might be useful in cases when MI diagnostics is complicated or if there are no ways to measure levels of troponins.

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