Biomarker Research (May 2023)

New cell sources for CAR-based immunotherapy

  • Marzieh Mazinani,
  • Fatemeh Rahbarizadeh

DOI
https://doi.org/10.1186/s40364-023-00482-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 27

Abstract

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Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Despite impressive clinical outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of CAR-T cells remain. While the main focus has been on improving CAR-T cells, exploring alternative cellular sources for CAR generation has garnered growing interest. In the current review, we comprehensively evaluated other cell sources rather than conventional T cells for CAR generation.

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