Nature Communications (Nov 2020)
Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma
- Siwei Wang,
- Mulong Du,
- Jingyuan Zhang,
- Weizhang Xu,
- Qianyu Yuan,
- Ming Li,
- Jie Wang,
- Hongyu Zhu,
- Yuzhuo Wang,
- Cheng Wang,
- Yuhua Gong,
- Xiaonan Wang,
- Zhibin Hu,
- David C. Christiani,
- Lin Xu,
- Hongbing Shen,
- Rong Yin
Affiliations
- Siwei Wang
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Mulong Du
- Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University
- Jingyuan Zhang
- Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Weizhang Xu
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Qianyu Yuan
- Department of Environmental Health, Harvard T. H. Chan School of Public Health
- Ming Li
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Jie Wang
- Department of Science and Technology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Hongyu Zhu
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Yuzhuo Wang
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Cheng Wang
- Department of Epidemiology and Biostatistics, International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University
- Yuhua Gong
- Geneplus-Beijing Institute
- Xiaonan Wang
- Geneseeq-Nanjing Technology Inc.
- Zhibin Hu
- Department of Epidemiology and Biostatistics, International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University
- David C. Christiani
- Department of Environmental Health, Harvard T. H. Chan School of Public Health
- Lin Xu
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- Hongbing Shen
- Department of Epidemiology and Biostatistics, International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University
- Rong Yin
- Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-020-19855-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Invasive early stage lung adenocarcinoma has a heterogeneous prognosis. Here, the authors microdissect malignant pulmonary nodules to invasive and preinvasive components and study the mutations that are common or private between the lesions, allowing them to understand the evolutionary path of the tumours.
