Effect β glucan extracted from Candida albicans on pathological changes produced by Penicillium chrysogenum infection in mice

Abstract

This research aims to evaluate the effect of β glucan extracted from Candida albicans on the pathological effect of P. chrysogenum isolated from subclinical bovine mastitis from Abu Ghraib area in Baghdad by California mastitis test in winter 2020 on some internal organs such as (bone, brain, lung and intestine) by intramammary injection for two weeks then the beta-glucan extracted from the yeast Candida albicans was used for treatment of P. chrysogenum infection at two concentrations 50 and 100 mg/kg by two methods of injection (intramammary and intraperitoneal). The present study findings demonstrated different degrees of inflammation in these organs especially in the bone and brain, in addition, treatment with beta-glucan extracted from C. albicans showed a strong recovery response at a 50 mg/kg concentration by intraperitoneal injection in all organs from a 100 mg/kg concentration intraperitoneal injection was better than intramammary injection. Additionally, the results showed that the concentration of IgG was determined in serum samples of mice infected with P. chrysogenum using radial immunodiffusion plate, which showed different diameters of precipitation rings in the gel of plate with an increase in IgG concentration in all mice compared to the normal value of the concentration of IgG.

Keywords

• β glucan
• bone
• brain
• lung
• rid plate