Synthesis of New Cisplatin Derivatives from Bile Acids
Barbara Seroka,
Zenon Łotowski,
Agnieszka Hryniewicka,
Lucie Rárová,
Rafal R. Sicinski,
Aneta M. Tomkiel,
Jacek W. Morzycki
Affiliations
Barbara Seroka
Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Zenon Łotowski
Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Agnieszka Hryniewicka
Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Lucie Rárová
Laboratory of Growth Regulators, Faculty of Science, Palacký University, and Institute of Experimental Botany of the Czech Academy of Sciences, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic
Rafal R. Sicinski
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
Aneta M. Tomkiel
Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Jacek W. Morzycki
Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
