Deverra tortuosa (Desf.) DC from Saudi Arabia as a new source of marmin and furanocoumarins derivatives with α-glucosidase, antibacterial and cytotoxic activities
Mohamed Habib Oueslati,
Arbi Guetat,
Jalloul Bouajila,
A. Khuzaim Alzahrani,
Jamith Basha
Affiliations
Mohamed Habib Oueslati
Northern Border University, College of Sciences, Department of Chemistry, Saudi Arabia; University of Carthage, Faculty of Science Bizerte, Laboratory of Hetero-Organic Compounds and Nanostructured Materials, Zarzouna, Tunisia; Corresponding author.
Arbi Guetat
Northern Border University, College of Sciences, Department of Biological Sciences, Saudi Arabia; University of Carthage, National Institute of Applied Science and Technology, Department of Biology, Laboratory of Plant Biotechnology, B.P. 676, 1080 Tunis Cedex, Tunisia
Jalloul Bouajila
Laboratoire de Génie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France
A. Khuzaim Alzahrani
Northern Border University, College of Applied Medical Sciences, Arar, Saudi Arabia
Jamith Basha
Northern Border University, College of Applied Medical Sciences, Arar, Saudi Arabia
Deverra tortuosa (Desf.) DC (Syn. Pituranthos tortusus (Desf.) Benth. & Hook.f.) is a species belonging to the Apiaceae family that is common in the Northern Region of Saudi Arabia. The plant is well known in traditional medicine along the Arabian ecoregion. In the framework of the present study, the crude extract of n-hexane and ethyl acetate of the seeds were fractionated to purify major bioactive secondary metabolites. Five compounds were identified for the first time from the seeds of D. tortuosa: Marmin 1, Pituranthoside 2, Isoimperatorin 3, Bergapten 4 and Isopimpinellin 5. Their structures were elucidated using 1D and 2D NMR, (ESI)-MS and IR spectroscopic analyses. The cytotoxic, α-glucosidase and antibacterial activities of the pure phytochemicals were also evaluated.
