Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection

Fang-Ju Cheng; Thanh-Kieu Huynh; Chia-Shin Yang; Dai-Wei Hu; Yi-Cheng Shen; Chih-Yen Tu; Yang-Chang Wu; Chih-Hsin Tang; Wei-Chien Huang; Yeh Chen; Chien-Yi Ho

doi:10.3390/nu13082800

Nutrients (Aug 2021)

Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection

Fang-Ju Cheng,
Thanh-Kieu Huynh,
Chia-Shin Yang,
Dai-Wei Hu,
Yi-Cheng Shen,
Chih-Yen Tu,
Yang-Chang Wu,
Chih-Hsin Tang,
Wei-Chien Huang,
Yeh Chen,
Chien-Yi Ho

Affiliations

Fang-Ju Cheng: Drug Development Center, China Medical University, Taichung 404, Taiwan
Thanh-Kieu Huynh: Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
Chia-Shin Yang: Institute of New Drug Development, China Medical University, Taichung 404, Taiwan
Dai-Wei Hu: Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
Yi-Cheng Shen: Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
Chih-Yen Tu: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung 404, Taiwan
Yang-Chang Wu: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Chih-Hsin Tang: Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
Wei-Chien Huang: Drug Development Center, China Medical University, Taichung 404, Taiwan
Yeh Chen: Drug Development Center, China Medical University, Taichung 404, Taiwan
Chien-Yi Ho: Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan

DOI: https://doi.org/10.3390/nu13082800
Journal volume & issue: Vol. 13, no. 8
p. 2800

Abstract

Read online

Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of HD with high bioavailability. Through the docking simulation, HD and HT have shown their potential to bind to two cellular proteins: transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2), which are required for the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our results further found that HT and HD suppressed the infection of VeroE6 cells using lentiviral-based pseudo-particles with wild types and variants of SARS-CoV-2 with spike (S) proteins, by blocking the interaction between the S protein and cellular receptor ACE2 and reducing ACE2 and TMPRSS2 expression. In summary, hesperidin is a potential TMPRSS2 inhibitor for the reduction of the SARS-CoV-2 infection.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

About the journal

Abstract

Keywords