Nature Communications (Sep 2016)

Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

  • Zeeshan Syedain,
  • Jay Reimer,
  • Matthew Lahti,
  • James Berry,
  • Sandra Johnson,
  • Richard Bianco,
  • Robert T. Tranquillo

DOI
https://doi.org/10.1038/ncomms12951
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Current vessel grafts must be surgically replaced when the recipient outgrows them. Here, Syedain et al.bioengineer a tube of acellular matrix produced from sheep fibroblasts that is capable of cellularizaton and somatic growth when transplanted into growing lambs, eliminating the need for multiple graft surgeries.