Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature
Shaqayeq Ramezanzade,
Mahsa Aeinehvand,
Heliya Ziaei,
Zohaib Khurshid,
Seied Omid Keyhan,
Hamid R. Fallahi,
James C. Melville,
Morvarid Saeinasab,
Farshid Sefat
Affiliations
Shaqayeq Ramezanzade
Section for Clinical Oral Microbiology, Department of Odontology Cariology and Endodontics, University of Copenhagen, DK-2200 Copenhagen, Denmark
Mahsa Aeinehvand
Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Tehran P.O. Box 14155-6559, Iran
Heliya Ziaei
Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Tehran P.O. Box 14155-6559, Iran
Zohaib Khurshid
Department of Prosthodontics and Dental Implantology, King Faisal University, Al-Ahsa 31982, Saudi Arabia
Seied Omid Keyhan
Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Isfahan P.O. Box 61355-45, Iran
Hamid R. Fallahi
Maxillofacial Surgery & Implantology & Biomaterial Research Foundation, Isfahan P.O. Box 61355-45, Iran
James C. Melville
Oral, Head & Neck Oncology and Microvascular Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Morvarid Saeinasab
Department of Biomedical and Electronic Engineering, School of Engineering, University of Bradford, Bradford BD7 1DP, UK
Farshid Sefat
Department of Biomedical and Electronic Engineering, School of Engineering, University of Bradford, Bradford BD7 1DP, UK
The current review aimed to assess the reliability and efficacy of tissue-engineered composite grafts in the reconstruction of large maxillofacial defects resulting from trauma or a benign pathologic disease. A systematic review of the literature was conducted using PubMed/Medline, Embase, and Scopus up to March 2022. The eligibility criteria included patients who had been treated with composite allogeneic tissue engineering for immediate/delayed reconstruction of large maxillofacial defects with minimum/no bone harvesting site. In the initial search, 2614 papers were obtained, and finally, 13 papers were eligible to be included in the current study. Most included papers were case reports or case series. A total of 144 cases were enrolled in this systematic review. The mean age of the patients was 43.34 (age range: 9–89). Most studies reported a successful outcome. Bone tissue engineering for the reconstruction and regeneration of crucial-sized maxillofacial defects is an evolving science still in its infancy. In conclusion, this review paper and the current literature demonstrate the potential for using large-scale transplantable, vascularized, and customizable bone with the aim of reconstructing the large maxillofacial bony defects in short-term follow-ups.
