Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications
Arun Kumar,
Mirkomil Sharipov,
Abbaskhan Turaev,
Shavkatjon Azizov,
Ismatdjan Azizov,
Edwin Makhado,
Abbas Rahdar,
Deepak Kumar,
Sadanand Pandey
Affiliations
Arun Kumar
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, India
Mirkomil Sharipov
Department of Chemistry, Changwon National University, Changwon 51140, Korea
Abbaskhan Turaev
Laboratory of Biological Active Macromolecular Systems, Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent 100125, Uzbekistan
Shavkatjon Azizov
Laboratory of Biological Active Macromolecular Systems, Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent 100125, Uzbekistan
Ismatdjan Azizov
State Center for Expertise and Standardization of Medicines, Medical Devices, and Medical Equipment, State Unitary Enterprise, Tashkent 100002, Uzbekistan
Edwin Makhado
Department of Chemistry, School of Physical and Mineral Sciences, University of Limpopo, Polokwane 0727, South Africa
Abbas Rahdar
Department of Physics, Faculty of Science, University of Zabol, Zabol 538-98615, Iran
Deepak Kumar
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, India
Sadanand Pandey
Department of Chemistry, College of Natural Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea
Globally, cancer is affecting societies and is becoming an important cause of death. Chemotherapy can be highly effective, but it is associated with certain problems, such as undesired targeting and multidrug resistance. The other advanced therapies, such as gene therapy and peptide therapy, do not prove to be effective without a proper delivery medium. Polymer-based hybrid nanoarchitectures have enormous potential in drug delivery. The polymers used in these nanohybrids (NHs) provide them with their distinct properties and also enable the controlled release of the drugs. This review features the recent use of polymers in the preparation of different nanohybrids for cancer therapy published since 2015 in some reputed journals. The polymeric nanohybrids provide an advantage in drug delivery with the controlled and targeted delivery of a payload and the irradiation of cancer by chemotherapeutical and photodynamic therapy.
