Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds
Shike Zhang,
Xin Chen,
Mengyao Shan,
Zijuan Hao,
Xiaoyang Zhang,
Lingxian Meng,
Zhen Zhai,
Linlin Zhang,
Xuying Liu,
Xianghong Wang
Affiliations
Shike Zhang
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Xin Chen
National Engineering Research Center of Wheat and Corn Further Processing, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China
Mengyao Shan
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Zijuan Hao
Henan Innovation Center for Functional Polymer Membrane Materials, Xinxiang 453000, China
Xiaoyang Zhang
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Lingxian Meng
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Zhen Zhai
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Linlin Zhang
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Xuying Liu
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Xianghong Wang
Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development. This review first introduces the commonly used nanomaterials in tissue engineering scaffolds, including natural polymers, synthetic polymers, and polymer derivatives, and reveals the improvement of nanomaterials on scaffold performance. Second, the 3D bioprinting technologies of inkjet-based bioprinting, extrusion-based bioprinting, laser-assisted bioprinting, and stereolithography bioprinting are comprehensively itemized, and the advantages and underlying mechanisms are revealed. Then the convergence of 3D bioprinting and nanotechnology applications in tissue engineering scaffolds, such as bone, nerve, blood vessel, tendon, and internal organs, are discussed. Finally, the challenges and perspectives of convergence of 3D bioprinting and nanotechnology are proposed. This review will provide scientific guidance to develop 3D bioprinting tissue engineering scaffolds by nanotechnology.
