Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments

Abstract

Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in emulating the complexity of the brain and the surrounding microenvironment to understand potential therapeutic approaches. This paper discusses some of the most important in vitro, in vivo, and microfluidic brain tumor models that aim to address these challenges.

Keywords

• Brain cancer
• Tumor microenvironment
• In vitro
• In vivo
• Microfluidics