The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

Yan Wang; Yanyan Chen; Juan Chen; Lijun Wang; Leitong Nie; Juanjuan Long; Haishuang Chang; Jian Wu; Chenhui Huang; Ming Lei

doi:10.1038/s41467-019-08437-1

Nature Communications (Feb 2019)

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

Yan Wang,
Yanyan Chen,
Juan Chen,
Lijun Wang,
Leitong Nie,
Juanjuan Long,
Haishuang Chang,
Jian Wu,
Chenhui Huang,
Ming Lei

Affiliations

Yan Wang: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, CAS Center for Excellence on Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yanyan Chen: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, CAS Center for Excellence on Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Juan Chen: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Lijun Wang: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, CAS Center for Excellence on Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Leitong Nie: National Key Laboratory of Crop Genetic Improvement, Huazhong Agriculture University
Juanjuan Long: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, CAS Center for Excellence on Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Haishuang Chang: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Jian Wu: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Chenhui Huang: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Ming Lei: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-08437-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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The TERB1-TERB2-MAJIN complex mediates the attachment of telomeres to the nuclear envelope. Here the authors present the crystal structures of the human TERB1-TERB2 and TERB2-MAJIN subcomplexes and show that Terb2 mutations, which abolish complex formation cause aberrant homologous pairing and disordered synapsis in mouse.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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