Nature Communications (Sep 2022)

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

  • Kaya J. E. Matson,
  • Daniel E. Russ,
  • Claudia Kathe,
  • Isabelle Hua,
  • Dragan Maric,
  • Yi Ding,
  • Jonathan Krynitsky,
  • Randall Pursley,
  • Anupama Sathyamurthy,
  • Jordan W. Squair,
  • Boaz P. Levi,
  • Gregoire Courtine,
  • Ariel J. Levine

DOI
https://doi.org/10.1038/s41467-022-33184-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Matson et al. performed single nucleus sequencing of the “spared” spinal cord tissue distal to an injury in mice. They found that spinocerebellar neurons expressed a pro-regenerative gene signature and showed axon outgrowth after injury.