Egyptian Liver Journal (Apr 2024)

Cholestatic liver injury secondary to over-the-counter cyproheptadine: case report and review of literature

  • Ayush Agarwal,
  • Arpit Shastri,
  • C. P. Ganesh,
  • Malvika Shastri,
  • Suvradeep Mitra,
  • Debadrita Ray,
  • Arka De

DOI
https://doi.org/10.1186/s43066-024-00333-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 5

Abstract

Read online

Abstract Background Cyproheptadine is an easily available over-the-counter first-generation antihistaminic that is often used as an appetite stimulant. Although it is usually a safe drug, rare instances of drug-induced liver injury may occur. Case presentation We report a case of cholestatic liver injury secondary to cyproheptadine in a young pharmacy student with chronic hepatitis B and review the literature of cyproheptadine-induced liver injury. Conclusion Although cyproheptadine is largely a safe drug, its potential for significant liver toxicity cannot be ignored.

Keywords