Higher mitochondrial DNA copy number is associated with metformin-induced weight loss

Jing Wang; Hua Liang; Rong Huang; Xiong Weng; Li Zheng; You Wang; Xueying Zheng; Zhenglong Gu; Fei Chen; Jian Shao; Zhaoxu Geng; Ewan R. Pearson; Jianping Weng; Wenying Yang; Tao Xu; Kaixin Zhou

doi:10.1038/s43856-023-00258-0

Communications Medicine (Feb 2023)

Higher mitochondrial DNA copy number is associated with metformin-induced weight loss

Jing Wang,
Hua Liang,
Rong Huang,
Xiong Weng,
Li Zheng,
You Wang,
Xueying Zheng,
Zhenglong Gu,
Fei Chen,
Jian Shao,
Zhaoxu Geng,
Ewan R. Pearson,
Jianping Weng,
Wenying Yang,
Tao Xu,
Kaixin Zhou

Affiliations

Jing Wang: College of Life Sciences, University of Chinese Academy of Sciences
Hua Liang: Department of Endocrinology and Metabolism, The Third Affiliated Hospital, Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Diabetology, Guangzhou
Rong Huang: Medical Science and Technology Innovation Center, Jinan Central Hospital, Shandong First Medical University
Xiong Weng: Division of Systems Medicine, School of Medicine, University of Dundee
Li Zheng: Institute of Biophysics, Chinese Academy of Sciences
You Wang: Institute of Biophysics, Chinese Academy of Sciences
Xueying Zheng: Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Zhenglong Gu: Center for Mitochondrial Genetics and Health, Greater Bay Area Institute of Precision Medicine
Fei Chen: College of Life Sciences, University of Chinese Academy of Sciences
Jian Shao: College of Life Sciences, University of Chinese Academy of Sciences
Zhaoxu Geng: Institute of Biophysics, Chinese Academy of Sciences
Ewan R. Pearson: Population Health and Genomics, School of Medicine, University of Dundee
Jianping Weng: Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Wenying Yang: Department of Endocrinology, China-Japan Friendship Hospital
Tao Xu: Institute of Biophysics, Chinese Academy of Sciences
Kaixin Zhou: College of Life Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s43856-023-00258-0
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 6

Abstract

Read online

Wang, Liang, Huang et al. evaluate associations between mitochondrial DNA copy number (mtDNA-CN) and HbA1c and weight loss in patients with type 2 diabetes treated with metformin or acarbose, as part of the MARCH study. They find that patients with higher mtDNA-CN lost more weight on metformin, but did not see the same with acarbose.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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