Антибиотики и Химиотерапия (May 2020)
The Antiviral Activity of the Sage-Leaved Rockrose Extract (Cistus Salviifolius) Against the Influenza Virus
Abstract
A study of the protective activity of the Sage-leaved Rockrose extract (Cistus salviifolius) and the biologically active additive Forcys in the MDCK cell culture and on the model of lethal influenza pneumonia in white mice was carried out.The studied extract inhibited the reproduction of all used influenza viruses. The most sensitive to it were the viruses A/California/07/09 (H1N1)pdm09, A/mallard/Pennsylvania/10218/84 (H5N2), and A/Vladivostok/02/09 (H1N1). The IC50 values of the listed viruses were 0.5, 0.5, and 0.4 μg/ml, and the selectivity indexes were 382, 382, and 478, respectively, which is characteristic for preparations with high antiviral activity. Type B influenza viruses were less sensitive to the extract.The inhibitory activity of the extract did not depend on the susceptibility or resistance of the viruses to the anti-influenza drugs used, oseltamivir and rimantadine. The reduction in specific mortality with influenza pneumonia in animals was 40% compared with the placebo group.The use of the biologically active supplement Forcys did not affect the infectious activity of the influenza virus in the tissues of the animals lungs and led to a moderate limitation of the degree of damage to lung tissue. The maximum effectiveness of the biologically active supplement Forcys was achieved with the therapeutic and prophylactic regimens of its use.
