Nature Communications (Apr 2016)

miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

  • Mengyang Zhao,
  • Rongcheng Luo,
  • Yiyi Liu,
  • Linyuan Gao,
  • Zhaojian Fu,
  • Qiaofen Fu,
  • Xiaojun Luo,
  • Yiyu Chen,
  • Xiaojie Deng,
  • Zixi Liang,
  • Xin Li,
  • Chao Cheng,
  • Zhen Liu,
  • Weiyi Fang

DOI
https://doi.org/10.1038/ncomms11309
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Although miR-related mechanisms have been implicated in nasopharyngeal carcinoma (NPC), a precise role for miR-3188 has not been reported in this context. Here, Zhao et al. show that FOXO1-induced miR-3188 acts as a tumour suppressor in NPC by regulating the axis mTOR/PI3K/Akt/c-Jun.