Nature Communications (Jan 2019)

A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

  • Joanes Grandjean,
  • Alberto Corcoba,
  • Martin C. Kahn,
  • A. Louise Upton,
  • Evan S. Deneris,
  • Erich Seifritz,
  • Fritjof Helmchen,
  • Isabelle M. Mansuy,
  • Edward O. Mann,
  • Markus Rudin,
  • Bechara J. Saab

DOI
https://doi.org/10.1038/s41467-018-08256-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment with SSRI.