Nature Communications (Mar 2020)
Grasp55 −/− mice display impaired fat absorption and resistance to high-fat diet-induced obesity
- Jiyoon Kim,
- Hyeyon Kim,
- Shin Hye Noh,
- Dong Geon Jang,
- Shi-Young Park,
- Dongkook Min,
- Hyunki Kim,
- Hee-Seok Kweon,
- Hoguen Kim,
- Sowon Aum,
- Sookyung Seo,
- Cheol Soo Choi,
- Hail Kim,
- Jae Woo Kim,
- Seok Jun Moon,
- Heon Yung Gee,
- Min Goo Lee
Affiliations
- Jiyoon Kim
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Hyeyon Kim
- Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry
- Shin Hye Noh
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Dong Geon Jang
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Shi-Young Park
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, and Department of Internal Medicine, Gachon University College of Medicine
- Dongkook Min
- Department of Biochemistry and Molecular Biology, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Hyunki Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Hee-Seok Kweon
- Center for Research Equipment, Korea Basic Science Institute
- Hoguen Kim
- Department of Pathology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine
- Sowon Aum
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Sookyung Seo
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Cheol Soo Choi
- Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, and Department of Internal Medicine, Gachon University College of Medicine
- Hail Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Jae Woo Kim
- Department of Biochemistry and Molecular Biology, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Seok Jun Moon
- Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry
- Heon Yung Gee
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- Min Goo Lee
- Department of Pharmacology, Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14912-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The physiological roles of the Golgi reassembly-stacking protein 55 (GRASP55/GORASP55) remain largely elusive. Here, the authors show that the Golgi-resident protein GRASP55 plays a crucial role in lipid homeostasis by regulating intestinal lipid uptake.
