Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

Francesco Ghini; Carmela Rubolino; Montserrat Climent; Ines Simeone; Matteo J. Marzi; Francesco Nicassio

doi:10.1038/s41467-018-05182-9

Nature Communications (Aug 2018)

Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

Francesco Ghini,
Carmela Rubolino,
Montserrat Climent,
Ines Simeone,
Matteo J. Marzi,
Francesco Nicassio

Affiliations

Francesco Ghini: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16
Carmela Rubolino: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16
Montserrat Climent: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16
Ines Simeone: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16
Matteo J. Marzi: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16
Francesco Nicassio: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT)—Via Adamello 16

DOI: https://doi.org/10.1038/s41467-018-05182-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Via the target-directed miRNA degradation process, RNAs can induce degradation of miRNAs by binding with extensive complementarity. Here, the authors show Serpine1 mRNA as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal