Nature Communications (Aug 2018)

Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

  • Francesco Ghini,
  • Carmela Rubolino,
  • Montserrat Climent,
  • Ines Simeone,
  • Matteo J. Marzi,
  • Francesco Nicassio

Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15


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Via the target-directed miRNA degradation process, RNAs can induce degradation of miRNAs by binding with extensive complementarity. Here, the authors show Serpine1 mRNA as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation.