Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Ilya Y. Shadrin; Brian W. Allen; Ying Qian; Christopher P. Jackman; Aaron L. Carlson; Mark E. Juhas; Nenad Bursac

doi:10.1038/s41467-017-01946-x

Nature Communications (Nov 2017)

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Ilya Y. Shadrin,
Brian W. Allen,
Ying Qian,
Christopher P. Jackman,
Aaron L. Carlson,
Mark E. Juhas,
Nenad Bursac

Affiliations

Ilya Y. Shadrin: Department of Biomedical Engineering, Duke University
Brian W. Allen: Department of Biomedical Engineering, Duke University
Ying Qian: Department of Biomedical Engineering, Duke University
Christopher P. Jackman: Department of Biomedical Engineering, Duke University
Aaron L. Carlson: Department of Biomedical Engineering, Duke University
Mark E. Juhas: Department of Biomedical Engineering, Duke University
Nenad Bursac: Department of Biomedical Engineering, Duke University

DOI: https://doi.org/10.1038/s41467-017-01946-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Cardiomyocytes derived from human induced pluripotent stem cells could be used to generate cardiac tissues for regenerative purposes. Here the authors describe a method to obtain large bioengineered heart tissues showing advanced maturation, functional features and engraftment capacity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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