Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening

• Ateequllah Hayat,
• Edward P. Carter,
• Hamish W. King,
• Aysegul Ors,
• Aaron Doe,
• Saul A. Teijeiro,
• Sarah Charrot,
• Susana Godinho,
• Pedro Cutillas,
• Hisham Mohammed,
• Richard P. Grose,
• Gabriella Ficz

Affiliations

Ateequllah Hayat

Institute of Medical and Biomedical Education, St George’s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK

Edward P. Carter

Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Hamish W. King

Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, VIC 3052, Australia

Aysegul Ors

Knight Cancer Institute, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098, USA

Aaron Doe

Knight Cancer Institute, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098, USA

Saul A. Teijeiro

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Sarah Charrot

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Susana Godinho

Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Pedro Cutillas

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Hisham Mohammed

Knight Cancer Institute, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098, USA

Richard P. Grose

Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK

Gabriella Ficz

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK