Protoberberine Isoquinoline Alkaloids from Arcangelisia gusanlung
Ling-Ling Yu,
Rong-Tao Li,
Yuan-Bao Ai,
Wei Liu,
Zhang-Shuang Deng,
Zhong-Mei Zou
Affiliations
Ling-Ling Yu
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China
Rong-Tao Li
Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Wanning 571533, China
Yuan-Bao Ai
School of Medicine, China Three Gorges University, Yichang 443002, China
Wei Liu
School of Medicine, China Three Gorges University, Yichang 443002, China
Zhang-Shuang Deng
China Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China
Zhong-Mei Zou
Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China
HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 2–15, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR, mass spectrometry, and CD analyses. Gusanlung E (1) expressed weak cytotoxic activity against the SGC 7901 cell line with an IC50 value of 85.1 µM.
