The association of aortic elasticity properties with novel inflammatory marker CRP /albumin ratio

Abstract

Objective Hypertension (HT) is the most important preventable cause of cardiovascular disease and mortality. Aortic elasticity parameters are affected in HT, and inflammation plays a central role in the development of HT. C-reactive protein (CRP) to albumin ratio (CAR) is a novel inflammatory marker. We aimed to evaluate the association of aortic elasticity properties with CAR. Methods A total of newly diagnosed untreated 101 hypertensive patients and 98 control participants were included to study. Clinical, demographic parameters, and blood sample parameters were recorded. Aortic strain, aortic stiffness index (ASI), and aortic distensibility (AoD) as aortic elasticity parameters were obtained from transthoracic echocardiography. Results CRP, CAR, ASI were significantly higher in hypertensive patients. (6.32 ± 2.48 vs 8.41 ± 3.35, p:<0.001; 0.158 ± 0.065 vs. 0.204 ± 0.083, p: <0.001; 6.73 ± 1.00 vs. 10.93 ± 1.81, p: <0.001, respectively) Aortic strain and AoD levels were significantly lower in hypertensive patients. (6.75 ± 2.17 vs 7.98 ± 2.27; p: <0.001 vs. 3.05 ± 0.97 vs 5.16 ± 1.01; p: <0.001, respectively) Conclusion CAR a novel inflammatory marker, which can be obtained from blood samples without additional time and cost, can be useful to predict aortic elasticity properties of hypertensive patients in daily clinical practice.

Keywords

• albumin
• aortic elasticity parameters
• c-reactive protein
• hypertension
• inflammation