SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

Julie Rageul; Jennifer J. Park; Ping Ping Zeng; Eun-A Lee; Jihyeon Yang; Sunyoung Hwang; Natalie Lo; Alexandra S. Weinheimer; Orlando D. Schärer; Jung-Eun Yeo; Hyungjin Kim

doi:10.1038/s41467-020-19162-5

Nature Communications (Oct 2020)

SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

Julie Rageul,
Jennifer J. Park,
Ping Ping Zeng,
Eun-A Lee,
Jihyeon Yang,
Sunyoung Hwang,
Natalie Lo,
Alexandra S. Weinheimer,
Orlando D. Schärer,
Jung-Eun Yeo,
Hyungjin Kim

Affiliations

Julie Rageul: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook
Jennifer J. Park: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook
Ping Ping Zeng: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook
Eun-A Lee: Center for Genomic Integrity, Institute for Basic Science
Jihyeon Yang: Center for Genomic Integrity, Institute for Basic Science
Sunyoung Hwang: Center for Genomic Integrity, Institute for Basic Science
Natalie Lo: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook
Alexandra S. Weinheimer: Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook
Orlando D. Schärer: Center for Genomic Integrity, Institute for Basic Science
Jung-Eun Yeo: Center for Genomic Integrity, Institute for Basic Science
Hyungjin Kim: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook

DOI: https://doi.org/10.1038/s41467-020-19162-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and protecting stalled forks by regulating the replication fork protection complex (FPC).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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