Nature Communications (Jan 2022)
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges
- João Faro-Viana,
- Marie-Louise Bergman,
- Lígia A. Gonçalves,
- Nádia Duarte,
- Teresa P. Coutinho,
- Patrícia C. Borges,
- Christian Diwo,
- Rute Castro,
- Paula Matoso,
- Vanessa Malheiro,
- Ana Brennand,
- Lindsay Kosack,
- Onome Akpogheneta,
- João M. Figueira,
- Conceição Cardoso,
- Ana M. Casaca,
- Paula M. Alves,
- Telmo Nunes,
- Carlos Penha-Gonçalves,
- Jocelyne Demengeot
Affiliations
- João Faro-Viana
- CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica
- Marie-Louise Bergman
- IGC, Instituto Gulbenkian de Ciência
- Lígia A. Gonçalves
- IGC, Instituto Gulbenkian de Ciência
- Nádia Duarte
- IGC, Instituto Gulbenkian de Ciência
- Teresa P. Coutinho
- CIISA, Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon
- Patrícia C. Borges
- IGC, Instituto Gulbenkian de Ciência
- Christian Diwo
- IGC, Instituto Gulbenkian de Ciência
- Rute Castro
- IBET, Instituto de Biologia Experimental e Tecnológica
- Paula Matoso
- IGC, Instituto Gulbenkian de Ciência
- Vanessa Malheiro
- IGC, Instituto Gulbenkian de Ciência
- Ana Brennand
- IGC, Instituto Gulbenkian de Ciência
- Lindsay Kosack
- IGC, Instituto Gulbenkian de Ciência
- Onome Akpogheneta
- IGC, Instituto Gulbenkian de Ciência
- João M. Figueira
- CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica
- Conceição Cardoso
- CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica
- Ana M. Casaca
- CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia Clínica
- Paula M. Alves
- IBET, Instituto de Biologia Experimental e Tecnológica
- Telmo Nunes
- CIISA, Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon
- Carlos Penha-Gonçalves
- IGC, Instituto Gulbenkian de Ciência
- Jocelyne Demengeot
- IGC, Instituto Gulbenkian de Ciência
- DOI
- https://doi.org/10.1038/s41467-021-27761-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Here, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age, sex, previous exposure, and treatments, while the 2nd dose is required to reach sero-conversion at the population level.
