Antidiabetic and antihyperlipidaemic potential of Amaranthus viridis (L.) Merr. in streptozotocin induced diabetic rats

Asian Pacific Journal of Tropical Disease. 2012;2(Sup 1):180-185 DOI 10.1016/S2222-1808(12)60148-0

 

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Journal Title: Asian Pacific Journal of Tropical Disease

ISSN: 2222-1808 (Print)

Publisher: Asian Pacific Journal of Tropical Disease Editorial Office

Society/Institution: Hainan Medical University

LCC Subject Category: Medicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine

Country of publisher: China

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Ramdas Pandhare (MES College of Pharmacy, Sonai, Newasa, Ahmednagar, India.)
Sangameswaran Balakrishnan (Principal& Director research, Adesh Institute of Pharmacy and Biomedical Sciences, Bathinda, Punjab)
Popat Mohite (MES College of Pharmacy, Sonai, Newasa, Ahmednagar, India.)
Shantaram Khanage (MES College of Pharmacy, Sonai, Newasa, Ahmednagar, India.)

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Time From Submission to Publication: 6 weeks

 

Abstract | Full Text

Objective: The present study is planned to investigate the antidiabetic and antihyperlipidaemic potential of Amaranthus viridis stem aqueous extract (AVSAE) in Stz-induced diabetic rats. Methods: Diabetes was induced in rats by single intraperitoneal injection of STZ (55mg/kg b.wt.). After 72 h rats with marked hyperglycaemia (fasting blood glucose ≥250 mg/dl) were selected and used for the study. Antidiabetic activity was evaluated by administration of AVSAE orally at the doses of 100,200 and 400 mg/kg body weight for 30 days. Glibenclamide (500 ug/kg) was used as the reference drug. Fasting blood glucose and lipid parameters, viz. triglycerides, total cholesterol, high density lipoprotein and low density lipoprotein levels were measured. Results: In STZinduced diabetic rats, repeated administration of AVSAE significantly (P< 0.05) decreased the blood glucose level in a dose-dependent manner during the 30 days of treatment period. AVSAE modulated lipid profile changes in STZ-diabetic rats in a dose-dependent manner. Conclusions: The significant control of serum lipids levels in the AVSAE treated diabetic rats may be directly attributed to improvement in glycemic control upon AVSAE therapy. Hence, these findings demonstrate that Amaranthus viridis has the potential to treat diabetes mellitus and complications owing to its antidiabetic and antihyperlipidaemic effect.