Frontiers in Psychiatry (May 2018)
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
- Céline S. Reinbold,
- Céline S. Reinbold,
- Andreas J. Forstner,
- Andreas J. Forstner,
- Andreas J. Forstner,
- Andreas J. Forstner,
- Andreas J. Forstner,
- Julian Hecker,
- Janice M. Fullerton,
- Janice M. Fullerton,
- Per Hoffmann,
- Per Hoffmann,
- Per Hoffmann,
- Per Hoffmann,
- Liping Hou,
- Urs Heilbronner,
- Franziska Degenhardt,
- Franziska Degenhardt,
- Mazda Adli,
- Kazufumi Akiyama,
- Nirmala Akula,
- Raffaella Ardau,
- Bárbara Arias,
- Lena Backlund,
- Antonio Benabarre,
- Susanne Bengesser,
- Abesh K. Bhattacharjee,
- Joanna M. Biernacka,
- Joanna M. Biernacka,
- Armin Birner,
- Cynthia Marie-Claire,
- Cynthia Marie-Claire,
- Pablo Cervantes,
- Guo-Bo Chen,
- Hsi-Chung Chen,
- Caterina Chillotti,
- Scott R. Clark,
- Francesc Colom,
- David A. Cousins,
- Cristiana Cruceanu,
- Piotr M. Czerski,
- Alexandre Dayer,
- Bruno Étain,
- Bruno Étain,
- Bruno Étain,
- Peter Falkai,
- Louise Frisén,
- Sébastien Gard,
- Julie S. Garnham,
- Fernando S. Goes,
- Paul Grof,
- Oliver Gruber,
- Ryota Hashimoto,
- Joanna Hauser,
- Stefan Herms,
- Stefan Herms,
- Stefan Herms,
- Stefan Herms,
- Stéphane Jamain,
- Esther Jiménez,
- Jean-Pierre Kahn,
- Layla Kassem,
- Sarah Kittel-Schneider,
- Sebastian Kliwicki,
- Barbara König,
- Ichiro Kusumi,
- Nina Lackner,
- Gonzalo Laje,
- Mikael Landén,
- Mikael Landén,
- Catharina Lavebratt,
- Marion Leboyer,
- Susan G. Leckband,
- Carlos A. López Jaramillo,
- Glenda MacQueen,
- Mirko Manchia,
- Mirko Manchia,
- Lina Martinsson,
- Manuel Mattheisen,
- Michael J. McCarthy,
- Susan L. McElroy,
- Marina Mitjans,
- Francis M. Mondimore,
- Palmiero Monteleone,
- Palmiero Monteleone,
- Caroline M. Nievergelt,
- Urban Ösby,
- Norio Ozaki,
- Roy H. Perlis,
- Andrea Pfennig,
- Daniela Reich-Erkelenz,
- Guy A. Rouleau,
- Peter R. Schofield,
- Peter R. Schofield,
- K. Oliver Schubert,
- Barbara W. Schweizer,
- Florian Seemüller,
- Giovanni Severino,
- Tatyana Shekhtman,
- Paul D. Shilling,
- Kazutaka Shimoda,
- Christian Simhandl,
- Christian Simhandl,
- Claire M. Slaney,
- Jordan W. Smoller,
- Alessio Squassina,
- Thomas J. Stamm,
- Thomas J. Stamm,
- Pavla Stopkova,
- Sarah K. Tighe,
- Alfonso Tortorella,
- Gustavo Turecki,
- Julia Volkert,
- Stephanie H. Witt,
- Adam J. Wright,
- L. Trevor Young,
- Peter P. Zandi,
- James B. Potash,
- J. Raymond DePaulo,
- Michael Bauer,
- Eva Reininghaus,
- Tomáš Novák,
- Jean-Michel Aubry,
- Mario Maj,
- Bernhard T. Baune,
- Philip B. Mitchell,
- Eduard Vieta,
- Mark A. Frye,
- Janusz K. Rybakowski,
- Po-Hsiu Kuo,
- Tadafumi Kato,
- Maria Grigoroiu-Serbanescu,
- Andreas Reif,
- Maria Del Zompo,
- Frank Bellivier,
- Frank Bellivier,
- Frank Bellivier,
- Martin Schalling,
- Naomi R. Wray,
- John R. Kelsoe,
- Martin Alda,
- Martin Alda,
- Francis J. McMahon,
- Thomas G. Schulze,
- Thomas G. Schulze,
- Thomas G. Schulze,
- Thomas G. Schulze,
- Thomas G. Schulze,
- Marcella Rietschel,
- Markus M. Nöthen,
- Markus M. Nöthen,
- Sven Cichon,
- Sven Cichon,
- Sven Cichon,
- Sven Cichon,
- Sven Cichon
Affiliations
- Céline S. Reinbold
- Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
- Céline S. Reinbold
- Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Andreas J. Forstner
- Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
- Andreas J. Forstner
- Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Andreas J. Forstner
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Andreas J. Forstner
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Andreas J. Forstner
- Department of Psychiatry (UPK), University of Basel, Basel, Switzerland
- Julian Hecker
- Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States
- Janice M. Fullerton
- Neuroscience Research Australia, Sydney, NSW, Australia
- Janice M. Fullerton
- School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
- Per Hoffmann
- Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
- Per Hoffmann
- Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Per Hoffmann
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Per Hoffmann
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Liping Hou
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Urs Heilbronner
- 0Department Psychiatry and Psychotherapy, Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany
- Franziska Degenhardt
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Franziska Degenhardt
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Mazda Adli
- 1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
- Kazufumi Akiyama
- 2Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan
- Nirmala Akula
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Raffaella Ardau
- 3Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
- Bárbara Arias
- 4Zoology and Biological Anthropology Section (Department of Evolutive Biology, Ecology and Environmental Sciences), Facultat de Biologia and Institut de Biomedicina, CIBERSAM, Universitat de Barcelona, Barcelona, Spain
- Lena Backlund
- 5Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
- Antonio Benabarre
- 6Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain
- Susanne Bengesser
- 7Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria
- Abesh K. Bhattacharjee
- 8Health Sciences Research, Mayo Clinic, Rochester, MN, United States
- Joanna M. Biernacka
- 9Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States
- Joanna M. Biernacka
- 0Institut National de la Santé et de la Recherche Médicale, U1144, Paris, France
- Armin Birner
- 7Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria
- Cynthia Marie-Claire
- 1Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France
- Cynthia Marie-Claire
- 2Department of Psychiatry, University of California, San Diego, San Diego, CA, United States
- Pablo Cervantes
- 3The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada
- Guo-Bo Chen
- 4Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
- Hsi-Chung Chen
- 5Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan
- Caterina Chillotti
- 3Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
- Scott R. Clark
- 6Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia
- Francesc Colom
- 7Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Spain
- David A. Cousins
- 8Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom
- Cristiana Cruceanu
- 9Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
- Piotr M. Czerski
- 0Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland
- Alexandre Dayer
- 1Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland
- Bruno Étain
- 1Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France
- Bruno Étain
- 2Department of Psychiatry, University of California, San Diego, San Diego, CA, United States
- Bruno Étain
- 2AP-HP, GH Saint-Louis – Lariboisière – F. Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France
- Peter Falkai
- 3Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
- Louise Frisén
- 5Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
- Sébastien Gard
- 4Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France
- Julie S. Garnham
- 5Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- Fernando S. Goes
- 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States
- Paul Grof
- 7Mood Disorders Center of Ottawa, Ottawa, ON, Canada
- Oliver Gruber
- 8Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany
- Ryota Hashimoto
- 9Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan
- Joanna Hauser
- 0Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland
- Stefan Herms
- Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
- Stefan Herms
- Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Stefan Herms
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Stefan Herms
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Stéphane Jamain
- 0Institut National de la Santé et de la Recherche Médicale U955, Psychiatrie Translationnelle, Créteil, France
- Esther Jiménez
- 6Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain
- Jean-Pierre Kahn
- 1Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France
- Layla Kassem
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Sarah Kittel-Schneider
- 2Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany
- Sebastian Kliwicki
- 3Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
- Barbara König
- 4Department of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria
- Ichiro Kusumi
- 5Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
- Nina Lackner
- 7Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria
- Gonzalo Laje
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Mikael Landén
- 6Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden
- Mikael Landén
- 7Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Catharina Lavebratt
- 5Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
- Marion Leboyer
- 8Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier - Henri Mondor, Pôle de Psychiatrie, Créteil, France
- Susan G. Leckband
- 9Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, United States
- Carlos A. López Jaramillo
- 0Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia
- Glenda MacQueen
- 1Department of Psychiatry, University of Calgary, Calgary, AB, Canada
- Mirko Manchia
- 2Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Mirko Manchia
- 3Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
- Lina Martinsson
- 4Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
- Manuel Mattheisen
- 5Department of Biomedicine, Aarhus University, Aarhus, Denmark
- Michael J. McCarthy
- 6Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, United States
- Susan L. McElroy
- 7Department of Psychiatry, Lindner Center of Hope/University of Cincinnati, Mason, OH, United States
- Marina Mitjans
- 4Zoology and Biological Anthropology Section (Department of Evolutive Biology, Ecology and Environmental Sciences), Facultat de Biologia and Institut de Biomedicina, CIBERSAM, Universitat de Barcelona, Barcelona, Spain
- Francis M. Mondimore
- 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States
- Palmiero Monteleone
- 8Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy
- Palmiero Monteleone
- 9Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Caroline M. Nievergelt
- 8Health Sciences Research, Mayo Clinic, Rochester, MN, United States
- Urban Ösby
- 0Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
- Norio Ozaki
- 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Roy H. Perlis
- 2Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
- Andrea Pfennig
- 3Department of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
- Daniela Reich-Erkelenz
- 0Department Psychiatry and Psychotherapy, Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany
- Guy A. Rouleau
- 4Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada
- Peter R. Schofield
- School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
- Peter R. Schofield
- 5Mental Illness, Neuroscience Research Australia, Sydney, NSW, Australia
- K. Oliver Schubert
- 6Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia
- Barbara W. Schweizer
- 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States
- Florian Seemüller
- 3Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
- Giovanni Severino
- 6Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
- Tatyana Shekhtman
- 8Health Sciences Research, Mayo Clinic, Rochester, MN, United States
- Paul D. Shilling
- 8Health Sciences Research, Mayo Clinic, Rochester, MN, United States
- Kazutaka Shimoda
- 7Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan
- Christian Simhandl
- 8Medical school, Sigmund Freud University, Vienna, Austria
- Christian Simhandl
- 9Bipolar Center Wiener Neustadt, Vienna, Austria
- Claire M. Slaney
- 5Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- Jordan W. Smoller
- 2Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
- Alessio Squassina
- 6Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
- Thomas J. Stamm
- 1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany
- Thomas J. Stamm
- 0Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School Brandenburg, Neuruppin, Germany
- Pavla Stopkova
- 1Department of Psychiatry, National Institute of Mental Health, Klecany, Czechia
- Sarah K. Tighe
- 2Department of Psychiatry, University of Iowa, Iowa, IA, United States
- Alfonso Tortorella
- 9Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Gustavo Turecki
- 9Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
- Julia Volkert
- 2Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany
- Stephanie H. Witt
- 3Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
- Adam J. Wright
- 4School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia
- L. Trevor Young
- 5Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
- Peter P. Zandi
- 6Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
- James B. Potash
- 2Department of Psychiatry, University of Iowa, Iowa, IA, United States
- J. Raymond DePaulo
- 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States
- Michael Bauer
- 3Department of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
- Eva Reininghaus
- 7Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria
- Tomáš Novák
- 1Department of Psychiatry, National Institute of Mental Health, Klecany, Czechia
- Jean-Michel Aubry
- 1Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland
- Mario Maj
- 9Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Bernhard T. Baune
- 6Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia
- Philip B. Mitchell
- 4School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia
- Eduard Vieta
- 6Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain
- Mark A. Frye
- 0Institut National de la Santé et de la Recherche Médicale, U1144, Paris, France
- Janusz K. Rybakowski
- 3Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
- Po-Hsiu Kuo
- 7Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
- Tadafumi Kato
- 8Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
- Maria Grigoroiu-Serbanescu
- 9Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
- Andreas Reif
- 2Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany
- Maria Del Zompo
- 6Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
- Frank Bellivier
- 1Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France
- Frank Bellivier
- 2Department of Psychiatry, University of California, San Diego, San Diego, CA, United States
- Frank Bellivier
- 2AP-HP, GH Saint-Louis – Lariboisière – F. Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France
- Martin Schalling
- 5Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
- Naomi R. Wray
- 4Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
- John R. Kelsoe
- 8Health Sciences Research, Mayo Clinic, Rochester, MN, United States
- Martin Alda
- 5Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
- Martin Alda
- 1Department of Psychiatry, National Institute of Mental Health, Klecany, Czechia
- Francis J. McMahon
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Thomas G. Schulze
- Intramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States
- Thomas G. Schulze
- 0Department Psychiatry and Psychotherapy, Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany
- Thomas G. Schulze
- 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States
- Thomas G. Schulze
- 8Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany
- Thomas G. Schulze
- 3Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
- Marcella Rietschel
- 3Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Markus M. Nöthen
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Sven Cichon
- Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland
- Sven Cichon
- Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Sven Cichon
- Institute of Human Genetics, University of Bonn, Bonn, Germany
- Sven Cichon
- Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
- Sven Cichon
- 0Research Centre Jülich, Institute of Neuroscience and Medicine (INM-1), Jülich, Germany
- DOI
- https://doi.org/10.3389/fpsyt.2018.00207
- Journal volume & issue
-
Vol. 9
Abstract
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs. However, it is unknown whether these miRNAs are also associated with lithium response in BD. In the present study, we therefore tested whether common variants at these nine candidate miRNAs contribute to the variance in lithium response in BD. Furthermore, we systematically analyzed whether any other miRNA in the genome is implicated in the response to lithium. For this purpose, we performed gene-based tests for all known miRNA coding genes in the ConLiGen GWAS dataset (n = 2,563 patients) using a set-based testing approach adapted from the versatile gene-based test for GWAS (VEGAS2). In the candidate approach, miR-499a showed a nominally significant association with lithium response, providing some evidence for involvement in both development and treatment of BD. In the genome-wide miRNA analysis, 71 miRNAs showed nominally significant associations with the dichotomous phenotype and 106 with the continuous trait for treatment response. A total of 15 miRNAs revealed nominal significance in both phenotypes with miR-633 showing the strongest association with the continuous trait (p = 9.80E-04) and miR-607 with the dichotomous phenotype (p = 5.79E-04). No association between miRNAs and treatment response to lithium in BD in either of the tested conditions withstood multiple testing correction. Given the limited power of our study, the investigation of miRNAs in larger GWAS samples of BD and lithium response is warranted.
Keywords
