Fetal Cortical Abnormalities Identified on Ultrasound
Mara Rosner,
Casey Reed,
Aylin Tekes,
Lindsey N. Goodman,
Angie C. Jelin,
Jena L. Miller,
Michelle L. Kush,
Ahmet A. Baschat,
Lisa R. Sun,
Jessica M. DeMay,
Kristin Baranano
Affiliations
Mara Rosner
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Casey Reed
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Aylin Tekes
Russell H. Morgan Department of Radiology and Radiological Science, Division of Pediatric Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Lindsey N. Goodman
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Angie C. Jelin
Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Jena L. Miller
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Michelle L. Kush
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ahmet A. Baschat
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Lisa R. Sun
Department of Neurology, Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Jessica M. DeMay
Independent Researcher, Richmond, VA 23233, USA
Kristin Baranano
Department of Neurology, Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Normal neuronal cell differentiation and migration is critical to brain formation, is rapidly occurring as the fetal brain develops, and peaks at the time of the routine ultrasound anatomic survey. Abnormalities in cortical migration can signify an underlying genetic abnormality or other fetal injury that can have a profound impact on future development. Although cortical migration peaks at 20–22 weeks, cortical migration abnormalities are rarely diagnosed at the time of the anatomic survey. We describe three cases of fetal cortical abnormalities in which prenatal ultrasound imaging was instrumental to making a prompt and accurate diagnosis in the mid-trimester and for guiding clinical counseling.
