Nature Communications (Jan 2021)
PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
- Daniela Nasteska,
- Nicholas H. F. Fine,
- Fiona B. Ashford,
- Federica Cuozzo,
- Katrina Viloria,
- Gabrielle Smith,
- Aisha Dahir,
- Peter W. J. Dawson,
- Yu-Chiang Lai,
- Aimée Bastidas-Ponce,
- Mostafa Bakhti,
- Guy A. Rutter,
- Remi Fiancette,
- Rita Nano,
- Lorenzo Piemonti,
- Heiko Lickert,
- Qiao Zhou,
- Ildem Akerman,
- David J. Hodson
Affiliations
- Daniela Nasteska
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Nicholas H. F. Fine
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Fiona B. Ashford
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Federica Cuozzo
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Katrina Viloria
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Gabrielle Smith
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Aisha Dahir
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Peter W. J. Dawson
- School of Sport, Exercise and Rehabilitation Science, University of Birmingham
- Yu-Chiang Lai
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- Aimée Bastidas-Ponce
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Mostafa Bakhti
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Guy A. Rutter
- Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Reproduction, and Digestion, Imperial College London
- Remi Fiancette
- Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham
- Rita Nano
- San Raffaele Diabetes Research Institute, IRCCS Ospedale
- Lorenzo Piemonti
- San Raffaele Diabetes Research Institute, IRCCS Ospedale
- Heiko Lickert
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München
- Qiao Zhou
- Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medical College
- Ildem Akerman
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- David J. Hodson
- Institute of Metabolism and Systems Research (IMSR), University of Birmingham
- DOI
- https://doi.org/10.1038/s41467-020-20632-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.
