Nature Communications (Jan 2020)

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection

  • Jumpei Omi,
  • Miho Watanabe-Takahashi,
  • Katsura Igai,
  • Eiko Shimizu,
  • Ching-Yi Tseng,
  • Tomohiro Miyasaka,
  • Tsuyoshi Waku,
  • Shinichiro Hama,
  • Rieka Nakanishi,
  • Yuki Goto,
  • Yuri Nishino,
  • Atsuo Miyazawa,
  • Yasuhiro Natori,
  • Makoto Yamashita,
  • Kiyotaka Nishikawa

DOI
https://doi.org/10.1038/s41467-019-13974-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into amphisomes, suggesting these to represent a type of anti-viral machinery.