Nature Communications (Jul 2016)

Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

  • Ioan Iacovache,
  • Sacha De Carlo,
  • Nuria Cirauqui,
  • Matteo Dal Peraro,
  • F. Gisou van der Goot,
  • Benoît Zuber

DOI
https://doi.org/10.1038/ncomms12062
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that provide insight into the conformational changes that allow pore formation.