Nature Communications (Jul 2016)
Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process
Abstract
Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that provide insight into the conformational changes that allow pore formation.