Unusual Polyhydroxylated Steroids from the Starfish <i>Anthenoides laevigatus</i>, Collected off the Coastal Waters of Vietnam

Alla  A. Kicha; Dinh  T. Ha; Timofey  V. Malyarenko; Anatoly  I. Kalinovsky; Roman  S. Popov; Olesya  S. Malyarenko; Tran  T. T. Thuy; Pham  Q. Long; Nguyen  T. T. Ha; Natalia  V. Ivanchina

doi:10.3390/molecules25061440

Molecules (Mar 2020)

Unusual Polyhydroxylated Steroids from the Starfish <i>Anthenoides laevigatus</i>, Collected off the Coastal Waters of Vietnam

Alla A. Kicha,
Dinh T. Ha,
Timofey V. Malyarenko,
Anatoly I. Kalinovsky,
Roman S. Popov,
Olesya S. Malyarenko,
Tran T. T. Thuy,
Pham Q. Long,
Nguyen T. T. Ha,
Natalia V. Ivanchina

Affiliations

Alla A. Kicha: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Dinh T. Ha: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Timofey V. Malyarenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Anatoly I. Kalinovsky: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Roman S. Popov: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Olesya S. Malyarenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Tran T. T. Thuy: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Pham Q. Long: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Nguyen T. T. Ha: Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Natalia V. Ivanchina: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia

DOI: https://doi.org/10.3390/molecules25061440
Journal volume & issue: Vol. 25, no. 6
p. 1440

Abstract

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Four new polyhydroxylated steroids 1−4 were isolated along with two previously known related steroids 5 and 6 from the methanolic extract of the starfish Anthenoides laevigatus collected off the coastal waters of Vietnam. Structures of new compounds were substantially elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and HRESIMS techniques. Heptaol 1 and hexaol 2 contain the common 5α-cholestane skeleton, while hexaol 3 and heptaol 4 have the rare among starfish steroid compounds 5β-cholestane skeleton. Compounds 1, 5, and 6 do not show cytotoxic effects against normal JB6 Cl41 and cancer HT-29 and MDA-MB-231 cells, however they inhibit cell proliferation and colony formation of cancer HT-29 and MDA-MB-231 cells.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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