Research progresses in delaying aging by targeting DNA damage repair

Zhang Weina; Chen Yu; Mao Zhiyong

doi:10.12287/j.issn.2096-8965.20230201

生物医学转化 (Jun 2023)

Research progresses in delaying aging by targeting DNA damage repair

Zhang Weina,
Chen Yu,
Mao Zhiyong

Affiliations

Zhang Weina: School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China
Chen Yu: School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China
Mao Zhiyong: School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China

DOI: https://doi.org/10.12287/j.issn.2096-8965.20230201
Journal volume & issue: Vol. 4, no. 2
pp. 2 – 12

Abstract

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Genomic instability is the primary hallmark of aging. Since DNA damage is one of the core aspects contributing to genomic instability, it has been long recognized as a critical cause of aging. Here, we summarized the interrelationship between DNA repair and aging, the mechanisms underlying how DNA damage contributes to aging, and discussed the possibility and potential risk of delaying aging by targeting DNA damage repair.

Published in 生物医学转化

ISSN: 2096-8965 (Print)
Publisher: Lanzhou University Press
Country of publisher: China
LCC subjects: Medicine; Technology: Chemical technology: Biotechnology
Website: http://swyxzh.ijournals.cn/swyxzhen/home

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