Research progresses in delaying aging by targeting DNA damage repair
Zhang Weina,
Chen Yu,
Mao Zhiyong
Affiliations
Zhang Weina
School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China
Chen Yu
School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China
Mao Zhiyong
School of Life Sciences and Technology, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai 201204, China
Genomic instability is the primary hallmark of aging. Since DNA damage is one of the core aspects contributing to genomic instability, it has been long recognized as a critical cause of aging. Here, we summarized the interrelationship between DNA repair and aging, the mechanisms underlying how DNA damage contributes to aging, and discussed the possibility and potential risk of delaying aging by targeting DNA damage repair.
