World Allergy Organization Journal (Mar 2025)
WAO - ARIA consensus on chronic cough: Executive summary
- Philip W. Rouadi, MD,
- Samar A. Idriss, MD,
- Jean Bousquet, MD, PhD,
- Mario Morais-Almeida, MD,
- Cecilio R. Azar, MD,
- Mona Sulaiman Al-Ahmad, MD,
- Anahí Yáñez, MD,
- Maryam Ali Y Al-Nesf, MD, MSc,
- Talal M. Nsouli, MD,
- Sami L. Bahna, MD, DrPH,
- Eliane Abou-Jaoude, MD,
- Fares H. Zaitoun, MD,
- Usamah M. Hadi, MD,
- Glenis K. Scadding, MD,
- Peter K. Smith, MBBS, PhD,
- René Maximiliano Gómez, MD, PhD,
- Sandra N. González-Díaz, MD, PhD,
- Ludger Klimek, MD, PhD,
- Georges S. Juvelekian, MD,
- Moussa A. Riachy, MD,
- Giorgio Walter Canonica, MD,
- David Peden, MD,
- Gary W.K. Wong, MD,
- James Sublett, MD,
- Jonathan A. Bernstein, MD,
- Lianglu Wang, MD,
- Luciana Kase Tanno, MD, PhD,
- Manana Chikhladze, PhD,
- Michael Levin, MBChB, MMed(Paeds), PhD,
- Yoon-Seok Chang, MD, PhD,
- Bryan L. Martin, DO,
- Luis Caraballo, MD, PhD,
- Adnan Custovic, MD, PhD,
- José Antonio Ortega-Martell, MD,
- Olivia J. Ly Lesslar, MBBS,
- Pedro Giavina-Bianchi, MD,
- Nikolaos Papadopoulos, MD, PhD,
- Elham Hossny, MD, PhD,
- Motohiro Ebisawa, MD, PhD,
- Alessandro Fiocchi,
- Ignacio J. Ansotegui, MD, PhD
Affiliations
- Philip W. Rouadi, MD
- Department of Otolaryngology, Dar Al Shifa Hospital, Hawally, Kuwait
- Samar A. Idriss, MD
- Department of Otolaryngology, Dar Al Shifa Hospital, Hawally, Kuwait; Corresponding author
- Jean Bousquet, MD, PhD
- Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany; MASK-air, Montpellier, France
- Mario Morais-Almeida, MD
- Allergy Center, CUF Descobertas Hospital, Lisboa, Portugal
- Cecilio R. Azar, MD
- Department of Gastroenterology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon; Department of Gastroenterology, Middle East Institute of Health (MEIH), Beirut, Lebanon; Department of Gastroenterology, Clemenceau Medical Center (CMC), Beirut, Lebanon
- Mona Sulaiman Al-Ahmad, MD
- Department of Microbiology, College of Medicine, Kuwait University, Kuwait
- Anahí Yáñez, MD
- INAER - Investigaciones en Alergia y Enfermedades Respiratorias, Buenos Aires, Argentina
- Maryam Ali Y Al-Nesf, MD, MSc
- Allergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar
- Talal M. Nsouli, MD
- International Cough Institute, Washington, DC, USA
- Sami L. Bahna, MD, DrPH
- Allergy & Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA
- Eliane Abou-Jaoude, MD
- International Cough Institute, Washington, DC, USA
- Fares H. Zaitoun, MD
- Allergy, Asthma and Immunology Center, Beirut, Lebanon; Clemenceau Medical Center Hospital, Dubai, United Arab Emirates
- Usamah M. Hadi, MD
- Clinical Professor Department of Otolaryngology Head and Neck Surgery, American University of Beirut, Lebanon
- Glenis K. Scadding, MD
- Department of ENT, RNENT Hospital and Division of Immunity and Infection, University College London, London, UK
- Peter K. Smith, MBBS, PhD
- Clinical Medicine Griffith University, Southport, Qld, 4215, Australia
- René Maximiliano Gómez, MD, PhD
- Faculty of Health Sciences, Catholic University of Salta, Argentina
- Sandra N. González-Díaz, MD, PhD
- Universidad Autónoma de Nuevo León, Hospital Universitario and Facultad de Medicina, Monterrey, Nuevo León, Mexico; Head and Professor Centro Regional de Alergia Asma e Inmunologia, Mexico
- Ludger Klimek, MD, PhD
- Center for Rhinology and Allergology, Wiesbaden, Germany
- Georges S. Juvelekian, MD
- Visiting Clinical Associate Professor of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
- Moussa A. Riachy, MD
- Department of Pulmonary and Critical Care, Hôtel-Dieu de France University Hospital, Beirut, Lebanon
- Giorgio Walter Canonica, MD
- Humanitas University & Personalized Medicine Asthma & Allergy Clinic-Humanitas Research Hospital-IRCCS-Milano, Italy
- David Peden, MD
- UNC Center for Environmental Medicine, Asthma, and Lung Biology, Division of Allergy, Immunology and Rheumatology, Department of Pediatrics UNC School of Medicine, USA
- Gary W.K. Wong, MD
- Department of Pediatrics, Chinese University of Hong Kong, Hong Kong, China
- James Sublett, MD
- Department of Pediatrics, Section of Allergy and Immunology, University of Louisville School of Medicine, 9800 Shelbyville Rd, Louisville, KY, USA
- Jonathan A. Bernstein, MD
- University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Cincinnati, OH, USA
- Lianglu Wang, MD
- Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, 100730, China
- Luciana Kase Tanno, MD, PhD
- Université Montpellier, Montpellier, France; Desbrest Institute of Epidemiology and Public Health, UMR UA-11, INSERM University of Montpellier, Montpellier, France; WHO Collaborating Centre on Scientific Classification Support, Montpellier, France
- Manana Chikhladze, PhD
- Medical Faculty at Akaki Tsereteli State University, National Institute of Allergy, Asthma & Clinical Immunology, KuTaisi, Tskaltubo, Georgia
- Michael Levin, MBChB, MMed(Paeds), PhD
- Division of Paediatric Allergology, Department of Paediatrics, University of Cape Town, South Africa
- Yoon-Seok Chang, MD, PhD
- Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea
- Bryan L. Martin, DO
- Department of Otolaryngology, Division of Allergy & Immunology, The Ohio State University, Columbus, OH, USA
- Luis Caraballo, MD, PhD
- Institute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia
- Adnan Custovic, MD, PhD
- National Heart and Lund Institute, Imperial College London, UK
- José Antonio Ortega-Martell, MD
- Health Science Institute, Autonomous University of Hidalgo, Mexico
- Olivia J. Ly Lesslar, MBBS
- The National Centre for Neuroimmunology and Emerging Disease, Griffith University, Southport, Qld, 4215, Australia
- Pedro Giavina-Bianchi, MD
- Clinical Immunology and Allergy Division, University of Sao Paulo, Brazil
- Nikolaos Papadopoulos, MD, PhD
- Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian, University of Athens, Athens, Greece; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
- Elham Hossny, MD, PhD
- Ain Shams University, Ain Shams University Children's Hospital, Cairo, Egypt
- Motohiro Ebisawa, MD, PhD
- Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan
- Alessandro Fiocchi
- Translational Pediatric Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Holy See
- Ignacio J. Ansotegui, MD, PhD
- Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
- Journal volume & issue
-
Vol. 18,
no. 3
p. 101034
Abstract
Acute cough is a highly prevalent symptom in clinical practice. Chronic cough is a complex disease with significant impact on quality of life. The mechanistic pathways of chronic cough in cough-comorbid clinical phenotypes are elusive. Mounting evidence suggests presence of a hypersensitive cough reflex and implication of transient receptor potential channels and P2X receptors in cough neuronal pathways. Previously, the World Allergy Organization (WAO)/Allergic Rhinitis and its Impact on Asthma (ARIA) Joint Committee on Chronic Cough published updated experimental and clinical data on chronic cough, in addition to a multidisciplinary care pathway approach to its management. The goal of this manuscript is to provide clinicians with a succinct summary of chronic cough pathophysiology, clinical phenotypes, and management strategies in both primary and cough specialty care. This executive summary is a primer for clinicians on chronic cough. Increasing awareness on the topic among primary care physicians will improve the outcome of management of patients with chronic cough.
