Sensing and Bio-Sensing Research (Dec 2023)
Fabrication, characterization and performance evaluation of an amplified electrochemical sensor based on MOFs nanocomposite for leukemia drug Imatinib determination
Abstract
In this research, the synthesis, fabrication steps and characterization of a new modified glassy carbon electrode (GCE) with CuFe2O4 magnetic nanoparticles combined with zeolitic imidazolate framework (ZIF-8) embedded graphene quantum dots (GQDs), (CuFe2O4/ZIF-8@GQDs), for electrodetermination of the imatinib (IMB), anti-cancer drug, are reported. The synthesized nanocomposite was characterized using X-ray powder diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and field emission scanning electron microscopy (FE-SEM). The GCE modified with CuFe2O4/ZIF-8@GQDs nanocomposite shows high electrocatalytic activity toward the oxidation of IMB compared with the bare GCE, GQDs/GCE, ZIF-8@GQDs/GCE, CuFe2O4/GCE and CuFe2O4@GQDs/GCE. The resulted electrocatalytic activity of the CuFe2O4/ZIF-8@GQDs/GCE can be attributed to the synergistic effect of the outstanding magnetic, electrical properties of the CuFe2O4/ZIF-8@GQDs and high conductivity of GQDs, as well as the high electron transport rate of the nanocomposite. Under optimized conditions, the developed sensor, CuFe2O4/ZIF-8@GQDs/GCE, has static properties such as wide linear range responses (0.02–11.85 and 11.85–94.20 μM), low detection limit (1.2 nM), high sensitivity (5.655 μA μM−1), long-term signal stability and reproducibility (RSD = 2.23%). It should be noted that the CuFe2O4/ZIF-8@GQDs/GCE sensor could be used for determination of IMB in biological and pharmaceutical samples, indicating its feasibility for real analysis.
