PHYSIOLOGY OF CHOLESTEROL METABOLISM (THE REVIEW)

Abstract

There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol. The pool of absorbed cholesterol in the ileum, contains 1/3 of dietary and. 2/3 of biliary cholesterol. Cholesterol concentration, in blood serum, depends on: 1) absorption, of dietary and. biliary cholesterol in the ileum; 2) absorption, of biliary cholesterol in the gallbladder; 3) activity of biosynthesis of cholesterol in the liver and the small intestine; 4) biosynthesis of bile acids in the liver; 5) speed, of elimination, of cholesterol from blood by liver; 6) rate of excretion of biliary cholesterol with, hepatic and. cystic bile into duodenum. Together with, enterohepatic circulation, of bile acids in human organism, there is enterohepatic circulation, of biliary cholesterol. It was proposed, that regulation, of concentration, of biliary cholesterol that participates in enterohepatic circulation, can influence a level of cholesterol in blood.

Keywords

• cholesterol
• bile acids
• enterohepatic circulation
• gallbladder
• absorption