Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

Magali de Bruyn; Christine Breynaert; Ingrid Arijs; Gert De Hertogh; Karel Geboes; Greet Thijs; Gianluca Matteoli; Jialiang Hu; Jo Van Damme; Bernd Arnold; Marc Ferrante; Séverine Vermeire; Gert Van Assche; Ghislain Opdenakker

doi:10.1038/ncomms15384

Nature Communications (May 2017)

Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease

Magali de Bruyn,
Christine Breynaert,
Ingrid Arijs,
Gert De Hertogh,
Karel Geboes,
Greet Thijs,
Gianluca Matteoli,
Jialiang Hu,
Jo Van Damme,
Bernd Arnold,
Marc Ferrante,
Séverine Vermeire,
Gert Van Assche,
Ghislain Opdenakker

Affiliations

Magali de Bruyn: Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven
Christine Breynaert: Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven
Ingrid Arijs: Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven
Gert De Hertogh: Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven
Karel Geboes: Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven
Greet Thijs: Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven
Gianluca Matteoli: Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven
Jialiang Hu: Key Laboratory of Modern Chinese Medicines, Ministry of Education, China Pharmaceutical University
Jo Van Damme: Department of Microbiology and Immunology, Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven
Bernd Arnold: Department of Molecular Immunology, German Cancer Research Center (DKFZ)
Marc Ferrante: Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven
Séverine Vermeire: Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven
Gert Van Assche: Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven
Ghislain Opdenakker: Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven

DOI: https://doi.org/10.1038/ncomms15384
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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