Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing
Yinghua Yu,
Laurentius Huber,
Jiajia Yang,
Masaki Fukunaga,
Yuhui Chai,
David C. Jangraw,
Gang Chen,
Daniel A. Handwerker,
Peter J. Molfese,
Yoshimichi Ejima,
Norihiro Sadato,
Jinglong Wu,
Peter A. Bandettini
Affiliations
Yinghua Yu
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA; Corresponding author.
Laurentius Huber
MR-Methods Group, MBIC, Cognitive Neuroscience Department, Faculty of Psychology and Neuroscience, University of Maastricht, Cognitive Neuroscience, Room 1.014, Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
Jiajia Yang
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
Masaki Fukunaga
Division of Cerebral Research, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585 Japan
Yuhui Chai
Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
David C. Jangraw
Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
Gang Chen
Scientific and Statistical Computational Core, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
Daniel A. Handwerker
Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
Peter J. Molfese
Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
Yoshimichi Ejima
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan
Norihiro Sadato
Division of Cerebral Research, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585 Japan
Jinglong Wu
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Beijing Institute of Technology, 5 South Zhongguancun Street, Hiadian District, Beijing 100081, China
Peter A. Bandettini
Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA; Functional MRI Core Facility, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA
The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input and generation of error signals. It remains unknown, however, how the layers in the human area 3b contribute to the temporal prediction error processing. To investigate prediction error representation in the area 3b across layers, we acquired layer-specific functional magnetic resonance imaging (fMRI) data at 7T from human area 3b during a task of index finger poking with no-delay, short-delay and long-delay touching sequences. We demonstrate that all three tasks increased activity in both superficial and deep layers of area 3b compared to the random sensory input. The fMRI signal was differentially modulated solely in the deep layers rather than the superficial layers of area 3b by the delay time. Compared with the no-delay stimuli, activity was greater in the deep layers of area 3b during the short-delay stimuli but lower during the long-delay stimuli. This difference activity features in the superficial and deep layers suggest distinct functional contributions of area 3b layers to tactile temporal prediction error processing. The functional segregation in area 3b across layers may reflect that the excitatory and inhibitory interplay in the sensory cortex contributions to flexible communication between cortical layers or between cortical areas.
