Frontiers in Public Health (Jul 2023)
A pedigree-based cohort to study the genetic risk factors for cardiometabolic diseases: study design, baseline characteristics and preliminary results
- Hongchen Zheng,
- Hongchen Zheng,
- Hongchen Zheng,
- Ying Ye,
- Hui Huang,
- Hui Huang,
- Chunlan Huang,
- Wenjing Gao,
- Wenjing Gao,
- Mengying Wang,
- Mengying Wang,
- Wenyong Li,
- Wenyong Li,
- Ren Zhou,
- Ren Zhou,
- Jin Jiang,
- Jin Jiang,
- Siyue Wang,
- Siyue Wang,
- Canqing Yu,
- Canqing Yu,
- Canqing Yu,
- Jun Lv,
- Jun Lv,
- Jun Lv,
- Xiaoling Wu,
- Xiaoming Huang,
- Weihua Cao,
- Weihua Cao,
- Yansheng Yan,
- Kuicheng Zheng,
- Tao Wu,
- Tao Wu,
- Tao Wu,
- Liming Li,
- Liming Li,
- Liming Li
Affiliations
- Hongchen Zheng
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Hongchen Zheng
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Hongchen Zheng
- Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing, China
- Ying Ye
- Department of Local Diseases Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China
- Hui Huang
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Hui Huang
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Chunlan Huang
- Department of Hygiene, Nanjing Country Center for Disease Control and Prevention, Nanjing, China
- Wenjing Gao
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Wenjing Gao
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Mengying Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Mengying Wang
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Wenyong Li
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Wenyong Li
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Ren Zhou
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Ren Zhou
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Jin Jiang
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Jin Jiang
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Siyue Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Siyue Wang
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Canqing Yu
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Canqing Yu
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Canqing Yu
- Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China
- Jun Lv
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Jun Lv
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Jun Lv
- Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China
- Xiaoling Wu
- Department of Hygiene, Nanjing Country Center for Disease Control and Prevention, Nanjing, China
- Xiaoming Huang
- Department of Hygiene, Nanjing Country Center for Disease Control and Prevention, Nanjing, China
- Weihua Cao
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Weihua Cao
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Yansheng Yan
- Department of Local Diseases Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China
- Kuicheng Zheng
- Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China
- Tao Wu
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Tao Wu
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Tao Wu
- Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China
- Liming Li
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Liming Li
- Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China
- Liming Li
- Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China
- DOI
- https://doi.org/10.3389/fpubh.2023.1189993
- Journal volume & issue
-
Vol. 11
Abstract
BackgroundWe initiated the Fujian Tulou Pedigree-based Cohort (FTPC) as the integration of extended pedigrees and prospective cohort to clarify the genetic and environmental risk factors of cardiometabolic diseases.MethodsFTPC was carried out in Nanjing County, Fujian Province, China from August 2015 to December 2017 to recruit probands with the same surnames and then enroll their first-degree and more distant relatives. The participants were asked to complete questionnaire interview, physical examination, and blood collection. According to the local genealogical booklets and family registry, we reconstructed extended pedigrees to estimate the heritability of cardiometabolic traits. The follow-up of FTPC is scheduled every 5 years in the future.ResultsThe baseline survey interviewed 2,727 individuals in two clans. A total of 1,563 adult subjects who completed all baseline examinations were used to reconstruct pedigrees and 452 extended pedigrees were finally identified, including one seven-generation pedigree, two five-generation pedigrees, 23 four-generation pedigrees, 186 three-generation pedigrees, and 240 two-generation pedigrees. The average age of the participants was 57.4 years, with 43.6% being males. The prevalence of hypertension, diabetes and dyslipidemia in FTPC were 49.2, 10.0, and 45.2%, respectively. Based on the pedigree structure, the heritability of systolic blood pressure, diastolic blood pressure, fast blood glucose, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein was estimated at 0.379, 0.306, 0.386, 0.452, 0.568, 0.852, and 0.387, respectively.ConclusionAs an extended pedigree cohort in China, FTPC will provide an important source to study both genetic and environmental risk factors prospectively.
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