Van Tıp Dergisi (Jul 2017)
Celiac Disease Antibody Frequency in Idiopathic Uveitis Patients
Abstract
INTRODUCTION: Uveitis is inflammation of layers of eye. The most common causes of uveititis are rheumatologic and infectious disease. Coeliac disease (CD) is a chronic inflammatory disease which is developed immunogically against gliadine. Herein, we aimed to investigate prevalence of CD among patients with idiopathic uveitis. METHODS: In this retrospective study, cohort was formed from subjects consulted by ophthalmology department for the investigation of uveitis of unknown cause. All patients were investigated for Behcet's disease, sarcoidosis and other rheumatic diseases by history and physical examination. Those patients who had no signs or symptoms directing a specific disease were scrutinized by laboratory examinations. Control group constituted Behcet's uveitis patients. All subjects were screened for anti-gliadin IgA and IgG and anti-transglutaminase antibodies. Duodenal biopsies were obtained whenever indicated. RESULTS: In this study, 45 idiopathic uveititis patients (median age 43,9+13,0) and 15 Behcet uveititis patients (median age 36,9+10,8) were included. Antibody positivity was detected in 7 of 45 patients in idiopathic uveititis group and in one of 15 patients in Behcet uveititis group. Antiglutaminase antibodies were detected in two patients of idiopathic group and none of Behcet uveititis group. One biopsy of idiopathic uveititis patient revealed CD findings. Interestingly, uveititis regressed with diet and former recurrent uveititis attacks entered remission in this patient. DISCUSSION AND CONCLUSION: CD, although not frequent, could be an underlying factor for uveitis and should be considered, especially if there are other clinical clues that suggest CD. However, routine screening for CD in patients with uveitis is not recommended.
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