Unraveling the influences of hemodynamic lag and intrinsic cerebrovascular reactivity on functional metrics in ischemic stroke
Luoyu Wang,
Xiumei Wu,
Jinyi Song,
Yanhui Fu,
Zhenqiang Ma,
Xiaoyan Wu,
Yiying Wang,
Yulin Song,
Fenyang Chen,
Zhongxiang Ding,
Yating Lv
Affiliations
Luoyu Wang
Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Department of radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, PR China; School of Biomedical Engineering, ShanghaiTech University, Shanghai, PR China
Xiumei Wu
Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China
Jinyi Song
Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China
Yanhui Fu
Department of Neurology, Anshan Changda Hospital, Anshan, Liaoning, PR China
Zhenqiang Ma
Department of Neurology, Anshan Changda Hospital, Anshan, Liaoning, PR China
Xiaoyan Wu
Department of Image, Anshan Changda Hospital, Anshan, Liaoning, PR China
Yiying Wang
Department of Ultrasonics, Anshan Changda Hospital, Anshan, Liaoning, PR China
Yulin Song
Department of Neurology, Anshan Changda Hospital, Anshan, Liaoning, PR China
Fenyang Chen
The Fourth school of Medical, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China
Zhongxiang Ding
Department of radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, PR China; Corresponding author at: Department of radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, PR China.
Yating Lv
Center for Cognition and Brain Disorders, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China; Corresponding author at: Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, PR China.
Resting-state functional magnetic resonance imaging (rs-fMRI) is a prominent tool for investigating functional deficits in stroke patients. However, the extent to which the hemodynamic lags (LAG) and the intrinsic cerebrovascular reactivity (iCVR) may affect the rs-fMRI metrics in different scales needs to be clarified for ischemic stroke. In this study, 73 ischemic stroke patients and 74 healthy controls (HC) were recruited to investigate how the correction of the LAG and/or iCVR would influence resting-state functional magnetic resonance imaging (rs-fMRI) metrics of three different spatial scales (local-scale, meso-scale and global-scale) in ischemic stroke. The analysis revealed that the Stroke pattern of all functional metrics using different correction strategies resembled the HC pattern. The highest overlap was observed in the Stroke pattern with correction for both LAG and iCVR, while the pattern without correction showed the lowest overlap. Most functional metrics after correction showed higher sensitivity in detecting between-group differences than those without correction. Moreover, our results were generally reproducible in an independent dataset. Collectively, these findings emphasize the necessity of considering LAG and iCVR effects to investigate stroke-related functional alterations, and highlight the significance of correction strategies for accurately interpreting the findings in rs-fMRI study of ischemic stroke.
