Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

Abstract

He Zhang, Zhao-qing Sun, Shuang-shuang Liu, Li-na Yang Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Abstract: The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine whether GRK4 and DRD1 polymorphisms influence the risk of hypertension and examined the relationship between the genetic variances and the etiology of hypertension. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, and sensitivity analysis were performed. A total of 15 articles containing 29 studies were finally included. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016–1.802, P=0.038). Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215–2.745, P=0.004) but not in East Asians and Africans. Rs4532 locus was associated with hypertension in East Asians (OR =1.833, 95% CI =1.415–2.376, P<0.001) but not in Caucasians. These data provide possible references for future case-control studies in hypertension. Keywords: GRK4, DRD1, hypertension, meta-analysis, gene polymorphism

Keywords

• GRK4
• DRD1
• Hypertension
• Meta-analysis
• Gene polymorphism