Therapeutic Advances in Medical Oncology (Sep 2024)

New frontiers in radioembolization

  • Arian Mansur,
  • Peiman Habibollahi,
  • Adam Fang,
  • Armeen Mahvash,
  • Vahid Etezadi,
  • Robert P. Liddell,
  • Juan C. Camacho,
  • Emil I. Cohen,
  • Nima Kokabi,
  • Aravind Arepally,
  • Christos Georgiades,
  • Nariman Nezami

DOI
https://doi.org/10.1177/17588359241280692
Journal volume & issue
Vol. 16

Abstract

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Radioembolization is a locoregional transarterial therapy that combines radionuclide and micron-sized beads to deliver radiation internally to the target tumors based on the arterial blood flow. While initially developed as a palliative treatment option, radioembolization is now used for curative intent treatment, neoadjuvant therapy, and method to downstage or bridge for liver transplant. Radioembolization has become increasingly utilized and is an important therapeutic option for the management of hepatocellular carcinoma and liver metastasis. This article provides an overview of the techniques, challenges, and novel developments in radioembolization, including new dosimetry techniques, radionuclides, and new target tumors.