Nature Communications (Jul 2016)
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
- Clint L. Miller,
- Milos Pjanic,
- Ting Wang,
- Trieu Nguyen,
- Ariella Cohain,
- Jonathan D. Lee,
- Ljubica Perisic,
- Ulf Hedin,
- Ramendra K. Kundu,
- Deshna Majmudar,
- Juyong B. Kim,
- Oliver Wang,
- Christer Betsholtz,
- Arno Ruusalepp,
- Oscar Franzén,
- Themistocles L. Assimes,
- Stephen B. Montgomery,
- Eric E. Schadt,
- Johan L.M. Björkegren,
- Thomas Quertermous
Affiliations
- Clint L. Miller
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Milos Pjanic
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Ting Wang
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Trieu Nguyen
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Ariella Cohain
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Jonathan D. Lee
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Ljubica Perisic
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Ulf Hedin
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Ramendra K. Kundu
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Deshna Majmudar
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Juyong B. Kim
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Oliver Wang
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Christer Betsholtz
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
- Arno Ruusalepp
- Department of Cardiac Surgery, Tartu University Hospital
- Oscar Franzén
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Themistocles L. Assimes
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Stephen B. Montgomery
- Department of Genetics, Stanford University School of Medicine
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Johan L.M. Björkegren
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Thomas Quertermous
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12092
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.
