Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment
Elena Avgoustou,
Ilektra Tzivaki,
Garyfalia Diamantopoulou,
Tatiana Zachariadou,
Despoina Avramidou,
Vasileios Dalopoulos,
Alexandros Skourtis
Affiliations
Elena Avgoustou
Second Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, Greece
Ilektra Tzivaki
First Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, Greece
Garyfalia Diamantopoulou
Second Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, Greece
Tatiana Zachariadou
First Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, Greece
Despoina Avramidou
Second Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Vasilissis Sofias 114, 11527 Athens, Greece
Vasileios Dalopoulos
First Department of Internal Medicine, Sismanogleio General Hospital, 37 Sismanogliou Str., 15126 Athens, Greece
Alexandros Skourtis
Department of Internal Medicine, Evangelismos General Hospital, 45-47 Ipsilantou Str., 10676 Athens, Greece
Obesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic alterations, insulin resistance, and lipid accumulation. These processes can culminate in histopathological changes collectively referred to as obesity-related glomerulopathy (ORG). This review aims to provide a comprehensive overview of the current knowledge regarding the prevalence, clinical manifestations, and pathophysiology of ORG. Furthermore, we emphasize the importance of identifying key biomarkers that facilitate the early detection of ORG. Finally, we explore emerging therapeutic strategies that offer promise in mitigating this growing global health crisis.
