MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease

Vanessa Desantis; Antonio Giovanni Solimando; Ilaria Saltarella; Antonio Sacco; Viviana Giustini; Marta Bento; Aurelia Lamanuzzi; Assunta Melaccio; Maria Antonia Frassanito; Angelo Paradiso; Monica Montagnani; Angelo Vacca; Aldo M. Roccaro

doi:10.3390/cancers13153650

Cancers (Jul 2021)

MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease

Vanessa Desantis,
Antonio Giovanni Solimando,
Ilaria Saltarella,
Antonio Sacco,
Viviana Giustini,
Marta Bento,
Aurelia Lamanuzzi,
Assunta Melaccio,
Maria Antonia Frassanito,
Angelo Paradiso,
Monica Montagnani,
Angelo Vacca,
Aldo M. Roccaro

Affiliations

Vanessa Desantis: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Antonio Giovanni Solimando: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Ilaria Saltarella: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Antonio Sacco: Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
Viviana Giustini: Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
Marta Bento: Centro Hospitalar Lisboa Norte, Department of Hematology and Transplantation, Institute of Molecular Medicine, University of Lisbon, 1649-035 Lisbon, Portugal
Aurelia Lamanuzzi: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Assunta Melaccio: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Maria Antonia Frassanito: Unit of General Pathology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Angelo Paradiso: IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy
Monica Montagnani: Department of Biomedical Sciences and Human Oncology, Pharmacology Section, Medical School, University of Bari “Aldo Moro”, 70124 Bari, Italy
Angelo Vacca: Unit of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
Aldo M. Roccaro: Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy

DOI: https://doi.org/10.3390/cancers13153650
Journal volume & issue: Vol. 13, no. 15
p. 3650

Abstract

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Multiple myeloma (MM) is a hematological malignancy characterised by proliferation of clonal plasma cells (PCs) within the bone marrow (BM). Myelomagenesis is a multi-step process which goes from an asymptomatic phase, defined as monoclonal gammopathy of undetermined significance (MGUS), to a smouldering myeloma (SMM) stage, to a final active MM disease, characterised by hypercalcemia, renal failure, bone lesions anemia, and higher risk of infections. Overall, microRNAs (miRNAs) have shown to significantly impact on MM tumorigenesis, as a result of miRNA-dependent modulation of genes involved in pathways known to be crucial for MM pathogenesis and disease progression. We aim to revise the literature related to the role of miRNAs as potential diagnostic and prognostic biomarkers, thus highlighting their key role as novel players within the field of MM and related premalignant conditions.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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