Nature Communications (Sep 2020)

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

  • Jing Yang,
  • Amanda McGovern,
  • Paul Martin,
  • Kate Duffus,
  • Xiangyu Ge,
  • Peyman Zarrineh,
  • Andrew P. Morris,
  • Antony Adamson,
  • Peter Fraser,
  • Magnus Rattray,
  • Stephen Eyre

DOI
https://doi.org/10.1038/s41467-020-18180-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to identify functional enhancers and demonstrate interactions of expression quantitative trait loci with target genes in rheumatoid arthritis.