Indian Journal of Radiology and Imaging (Oct 2024)

Pretherapeutic PSMA PET-Derived Semiquantitative Parameters as Predictors of PSA Response in Patients with mCRPC Receiving [<sup>177</sup>Lu]Lu-PSMA-617 Radioligand Therapy

  • Dheeratama Siripongsatian,
  • Attapon Jantarato,
  • Chetsadaporn Promteangtrong,
  • Anchisa Kunawudhi,
  • Peerapon Kiatkittikul,
  • Natphimol Boonkawin,
  • Sukanya Yaset,
  • Sirinsuda Somboon,
  • Chanisa Chotipanich

DOI
https://doi.org/10.1055/s-0044-1779634
Journal volume & issue
Vol. 34, no. 04
pp. 579 – 587

Abstract

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Objective [177Lu]Lu-prostate-specific membrane antigen (PSMA)-617 radioligand therapy (RLT) shows promise for metastatic castration-resistant prostate cancer (mCRPC) patients with positive PSMA positron emission tomography (PET) imaging. Identifying high-risk patients is crucial. We evaluated pretherapeutic PSMA PET-derived parameters to predict prostate-specific antigen (PSA) response in patients undergoing [177Lu]Lu-PSMA-617 RLT.

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